Antibacterial activity of the cationic biocide 1-dodecylpyridinium tetrafluoroborate against multidrug-resistant strain of Acinetobacter baumannii

Authors

  • S.P. Rogalsky V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of NASU
  • D.M. Godyna V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of NASU
  • I.V. Semeniuta V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of NASU
  • O.P. Tarasyuk V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of NASU
  • L.O. Metelytsia V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of NASU

DOI:

https://doi.org/10.18372/2306-6407.1.18101

Keywords:

cationic biocide, antibacterial activity, multi-drug resistant strains, molecular docking

Abstract

Hydrophobic cationic biocide 1-dodecylpyridinium tetrafluoroborate (PyrC12-BF4) has been synthesized. The antibacterial activity of cationic biocide against antibiotic-resistant strains-isolates of Acinetobacter baumannii has been established. According to results of molecular docking, the inhibition of the active site FabG may be one of the possible mechanisms of anti-A. baumannii activity of the PyrC12-BF4.

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Published

2023-12-12

Issue

No. 1 (2023)

Section

Experimental articles