Вioengineering technologies in the treatment of nervous system pathology

Authors

  • L.D. Liubich The State Institution “Romodanov Neurosurgery Institute”, National Academy of Medical Sciences of Ukraine
  • L.P. Staino The State Institution “Romodanov Neurosurgery Institute”, National Academy of Medical Sciences of Ukraine
  • D.M. Yehorova The State Institution “Romodanov Neurosurgery Institute”, National Academy of Medical Sciences of Ukraine
  • N.P. Oleksenko The State Institution “Romodanov Neurosurgery Institute”, National Academy of Medical Sciences of Ukraine
  • V.V. Medvediev The State Institution “Romodanov Neurosurgery Institute”, National Academy of Medical Sciences of Ukraine

DOI:

https://doi.org/10.18372/2306-6407.1.18037

Keywords:

spinal cord injury, fibrin matrix, neural stem / progenitor cells, GFAP astrocytes, β-tubulin III neurons

Abstract

Cell therapy using stem/progenitor cells (SPCs), regenerative biomaterials, tissue engineering technologies, and their combination is considered an effective strategy for the treatment of central nervous system (CNS) pathology. Bioengineering technologies are of particular importance in cases of CNS traumatic lesions, primarily for the purpose of filling traumatic cavities and providing adsorption loci for transplanted or endogenous cells; as well as to suppress the apoptosis, inflammation, glial scars formation and stimulation of neurogenesis, axons sprouting and angiogenesis. The aim – to study the effect of implantation of fibrin matrix (FM) associated with neural SPCs on the rat spinal cord tissue after spinal cord injury.

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Published

2023-12-12

Issue

No. 1 (2023)

Section

Experimental articles