Dynamic properties of the time series of biomedical measurement
DOI:
https://doi.org/10.18372/2310-5461.46.14811Keywords:
functional state, time series, F-statistics, trends, factor influenceAbstract
The paper develops and investigates a parametric model of the dynamics of measurement results and proposes its use for unilateral classification (control of significance) of local and global disturbances in functional models of the dynamic equilibrium of the biological state. Existing methods for estimating the accuracy of measurements have been improved, the sequence of results of which is modeled by local-nonstationary time series. A probabilistic model of time-distributed measurement results has been developed, taking into account the stochastic influence of factors of inhomogeneity of experimental conditions and biological instability of the studied object. The analysis of additive and multiplicative elements of the probabilistic model, which is responsible for its global and local changes, is carried out. The information properties of the elements of the probabilistic model and the statistical synthesis of its informative parameters are investigated. A method of parametric control of the stability of the processes of biological functioning and finding disturbances of the dynamic equilibrium of biological objects by the results of long-term passive and active biomedical experiments has been developed. The assessment of the reliability of the control of both the biological stability of the object of study and the metrological homogeneity of the entire biomedical measurement experiment. Calculations the information’s parameters for F statistics on medico-biological indicators of experimental researches of Antarctic winterers of 21 Antarctic expeditions are carried out. The results of passive and active load experiments were processed and the proposed model was tested for adequacy.
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