MATHEMATICAL MODELS FOR DEVELOPMENT AND COMPENSATION OF HYPOXIC STATES DURING ISCHEMIC HEART DISEASE IN FLIGHT CREWS’ PERSONNEL
DOI:
https://doi.org/10.18372/1990-5548.59.13644Keywords:
Ischemic heart disease, hypoxic state compensation, mathematical model of respiratory gases mass transfer, pharmacological correction of hypoxic state, cardiovascular pathologies’ of pilotsAbstract
The increase of pilots’ labor intensity caused by rapid development of flight technologies and increasing of complexity of combat missions faced by flight crew members increases the loads on organisms of flight personnel in general and in particular on their cardiovascular system. Domestic and foreign sources contain statistics indicating an increase in the number of flight accidents caused by cardiovascular pathologies in pilots, an increase in the number of flight personnel unsuitable for flight work due to the same reasons, a decrease in the age of flight crew members with cardiovascular pathologies. Therefore, issues of early detection and optimization of treatment processes of cardiovascular diseases in flight crew members are really necessary. Unfortunately, the possibilities of only instrumental approach to optimize the choice of ways for circulatory hypoxia correction in persons of aircrews caused by ischemic heart disease are rather limited. Simulation of the process of disease course for various methods of treatment by administering a pharmacological preparation can provide substantial assistance. This paper presents mathematical model of ischemic heart disease development in flight personnel, consisting on mathematical model of respiratory gas transport in pilot's organism, the model of conflict-controlled processes during self-organization of functional respiratory system, supplemented by differential equations describing changes in oxygen pressure in arterial blood during arteries stenosis caused by ischemic heart disease and equations describing the transport of pharmacological drug used for the treatment. Such composition of model, in case of its individualization, will optimize the treatment process by imitation of introduction of various drugs. Various methods of drug administration also were modeled - respiratory, oral, intramuscular and intravenous.
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