EOSINOPHILIC GASTRITIS IN CHILDREN

Abstract

The article presents characteristics of morphological and immunohistochemical changes of the gastric mucosa in children with eosinophilic gastritis. The course of eosinophilic gastritis in children is characterized by an imbalance of cell regeneration processes. It was found that most children were diagnosed with hemorrhage, microthrombosis, stromal fibrosis, proliferation of fibroblasts and collagen fibers. In a process of immunohistochemical examination of gastric biopsies, most children with eosinophilic gastritis revealed uneven expression of the VEGFR 1 receptor in gastric endothelial cells. Type IV collagen expression was determined in the individual fragmented foci in the basement membranes of the superficial epithelium and single glandular structures. Advanced expression of TGFRβ positive cellular elements was diagnosed only in patients with severe gastric mucosal fibrosis. The data that has been collected indicates that the course of eosinophilic gastritis is accompanied by microcirculation disorders and stromal-epithelial change of the gastric mucosa.