• Oksana Kryvosheyeva National Aviation University
  • Katerina Garkava National Aviation University
  • Larysa Natrus Bogomolets National Medical University



cholesterol, Сitrullus colocynthis, diabetes mellitus, fatty acids, lipoproteins, triglycerides


Purpose: To investigate the effect of microdoses of fatty acids (FA) of partially defatted dry Citrullus colocynthis extract on the lipid metabolism of rats with type 1 diabetes mellitus (DM) has been studied. Methods: Raw materials were degreased by extraction in a Soxhlet apparatus under conditions of shortening the evaporation time. With the help of gas-liquid chromatographic research, trace concentrations of FA were revealed in the composition of the obtained dry extract of Citrullus colocynthis. Results: It was found that the introduction of the extract of the Citrullus colocynthis vegetal solution with a dose of 400 mg/kg to rats causes redistribution of the classes of lipoproteins to the values of the control group. The dose of 200 mg/kg – does not cause statistically significant changes in plasma lipoproteins. Conclusions: Finally the Citrullus colocynthis extract containing micro doses of FA in their uniform distribution has a positive effect on lipid metabolism, does not bring to an increase of level of the total cholesterol, does not cause an increase of body weight.

Author Biographies

Oksana Kryvosheyeva, National Aviation University


Department of Biotechnology, National Aviation University.

Education: bachelor, National Aviation University, Kyiv, Ukraine (2016).

Research area: biotechnology, biology, theoretical medicine.

Katerina Garkava, National Aviation University

Doctor of Biology, Professor.

Head of the Department of Biotechnology, National Aviation University.

Education: Kyiv National Taras Shevchenko University, Kyiv, Ukraine (1974).

Research area: biotechnology, biology, ecobiotechnology, immunology.

Larysa Natrus, Bogomolets National Medical University

Doctor of Medicine, Professor.

Director of Scientific and Research Institute of Experimental and Clinical Medicine, Bogomolets National Medical University.

Education: Donetsk National Medical Gorky University, Donetsk, Ukraine (1994).

Research area: neurophysiology, clinical laboratory medicine, neurobiology, biology.


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How to Cite

Kryvosheyeva, O., Garkava, K., & Natrus, L. (2017). INFLUENCE OF MICRODOSE OF FATTY ACIDS OF CITRULLUS COLOCYNTHIS EXTRACT ON LIPOPROTEIDS OF RAT BLOOD WITH DIABETES MELLITUS TYPE 1. Proceedings of National Aviation University, 73(4), 74–80.